Parkinson’s disease (PD) is the second most common neurodegenerative disorder mainly affecting movement function. The long-term goal of my laboratory is to elucidate the pathogenic mechanisms of PD and reveal new potential therapeutic targets for the treatment of PD. Specifically, we will investigate how the impaired synaptic membrane trafficking results in selective neurodegeneration of dopaminergic neurons in PD. We will also study the potential synergistic function of several PD-linked proteins on synaptic endocytic pathway. We will use a combination of biochemical, cell biological, genetic, physiological, pathological and behavioral approaches to address these questions on PD mouse models and iPSC-derived human patient neurons.